Acanthosis nigricans is a skin change where your skin becomes darker, thicker, and often has a velvety feel, usually found in body folds like the armpits, groin, or neck. Most of the time, it’s linked to obesity, diabetes, or insulin resistance. But here’s the weird twist: it can also be an early sign of colon cancer—especially a type called colorectal adenocarcinoma—if it appears suddenly or gets much worse for no clear reason.
While common among people with weight or metabolic issues, in rare cases acanthosis nigricans appears in people with GI cancers, sometimes even before any other symptoms show up. If you (or someone you care for) develops new or rapidly worsening, velvety, dark skin patches for no apparent reason, especially if they aren’t overweight or diabetic, it’s time to get checked out. Both this and the Lesser-Trelat sign can even happen together.
3. Acquired Hypertrichosis Lanuginosa (Sudden Fuzzy Hair Growth)
This last sign is the rarest, but arguably the weirdest. Hypertrichosis lanuginosa is when fine, soft, unpigmented “lanugo” hair (like the kind newborns have) suddenly starts growing on parts of the body, including the face, ears, nose, trunk, and limbs—except the palms, soles, or perineum. While this fuzzy hair growth can be linked to metabolic or hormone problems, in very rare situations it can point to internal cancers like colon (as well as lung or breast) cancer.
Here’s what’s even stranger: this new hair growth might show up as much as two and a half years before the actual tumor is found. If you, or a friend or family member, suddenly gets much hairier without explanation, or starts growing soft baby-like hair in new places, this is a sign to have a medical check-up.
Other Common Signs of Colon Cancer (Just So You Know)
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